Somno-Art Solution is an ambulatory innovative medical device that simplifies sleep recording and analysis.
Our innovation opens the way to record more rapidly and easily patients’ sleep, and to asses sleep patterns, abnormalities and pathologies on large scale.
Thanks to Somno-Art, clinicians and doctors have a new tool at their disposal.
Sleep is an important biomarker in the drug development market. Somno-Art Solution is the perfect tool for clinicians who use sleep as a primary or secondary endpoint, and need clear feedbacks of their therapies’ impact on sleep.
Moreover, this solution allow recordings on large cohorts with minimal discomfort for patients and simplified uses for the research team.
Offering Clinical Data to Doctors and Patients
Chronic disorders can affect up to 30% of the general population, and more than half of the population experience at least one sleep disorder event every year. More than 3 out of 4 people will never pass a sleep diagnostic evaluation.
The consequences of poor sleep are today well-known: higher risk of diabetes, obesity, mood disorders, hypertension, lack of vigilance leading to industrial accidents…
With Somno-Art, physicians have now the ability to quickly diagnose the quality of sleep of their patients, to continuously monitor their sleep, and to understand the possible adverse-effects of prescribed therapies. Doctors can better assist their patients to improve their sleep and quality of life.
Heart rate and body motor activity can be used to discriminate between wake and sleep as well as to distinguish all sleep stages and their transitions. These two physiological measures are used by the software to automatically score the hypnogram.
A fully automated, wearable device will allow the user-friendly recording of sleep and vigilance states…
… Independent of location of the user (home, clinic, travel)
Several studies have been conducted recording with PSG, heart rate and body motility devices on healthy volunteers and patients with sleep or CNS disorders
Sleep architecture and continuity results obtained through Somno-Art were equivalent to those obtained by manual analysis of simultaneously recorded PSG.
The first version of the device, currently under development, will allow robust and precise data acquisitions of heart beats and body movements.
The versions to follow will extend the data collection during the 24-hour period
Our team has conducted a first study with sixty 24-hour recordings including heart rate and body motility of healthy volunteers. We have shown that the sleep architecture and continuity results obtained with Somno-Art were equivalent to those obtained by manual analysis of simultaneously recorded PSG.
These results have been published in Sleep Medicine, the official journal of the World Association of Sleep Medicine and International Pediatric Sleep Association.
Figure 1: Comparative hypnograms between Somno-Art and visual scorers the corresponding hypnograms are obtained from the PSG A, Somno-Art scoring and PSG B for a same recorded night.
Figure 2: Comparison of sleep architecture measures obtained from polysomnography manual scoring versus heart rate and wrist movements automatic scoring (average values calculated over the 48 nights recorded)
New studies are currently conducted on patients with sleep-related disorders.
Our R&D team is always working on the solution in order to improve both the devise and the software.
Currently, the main developments concern the detection of sleep disorders and the incorporation of questionnaires and cognitive tests.
By improving our algorithms, and adding environmental parameter recordings to the device, the next generation of Somno-Art will be able to alert for possible sleep disorders, including aponeas and restless leg.
The next generation of Somno-Art Solution will also allow the users to record their environmental parameters. These information will improve sleep diagnostics by providing the light, sound and temperature levels recorded during the night.
Doctor of Medecine
Alain is a M.D. and graduated from the Faculty of Medicine of Strasbourg. He is a former Director of Research at the CNRS and former Secretary of the European Sleep Research Society. He has more than 50 years of research experience and more than 170 publications on sleep and alertness.
PhD in neurosciences
Prior to joining Index, Rémy was the President and CEO of Forenap group, a research organization in neurosciences and drug development based in France. He is the author of about 50 publications, served on advisory boards of biotech as well as pharmaceutical companies and has been involved in the development of more than 150 CNS active molecules and has carried out more than 700 clinical trials.
Doctorate degree in Pharmacy
Jean-Yves has a doctorate degree in Pharmacy, a Master ‘s degree in Industrial Pharmacy and in Biological and Medical Sciences from the University of Strasbourg and a specialized master’s degree in “Management of the Pharmaceutical Industry” from ESC Dijon. He has over 15 years of experience in Drug Development.
PPRS, the Strategic Partnering Organization, is accompanying Somno-Art, and is managing a team of more than 20 people to develop the solution.
Finance & Strategy
Fabrice has a Master’s degree in public law (University Pantheon-Sorbonne) and graduated from IEP Paris (Institut des Etudes Politiques). He has a 15-year experience in corporate finance at Compagnie Financiere E. Rothschild and BNP Paribas.
Jay B. SAOUD
CEO, PPRS Research, Inc. (US subsidiary)
Jay holds a doctorate in Experimental Cognition from City University of New York. He has more than 24 years of R&D experience that spanned research at academia, CRO, biotechnology startups, and large pharma, culminating as a compound development team leader & head of exploratory development at Transform Pharmaceuticals, a J&J company. His areas of expertise include clinical development plans, directing clinical studies, and hands on pharmacokinetics & statistical analysis. He is the co-author of more than 35 peer-reviewed publications and 100 abstracts.
Baptiste has a master’s degree in Banking and Finance from the University Pantheon-Sorbonne. He has a 4-year experience in corporate finance.
Head of Clinical Operations
Elisabeth holds a degree in nursing and, in addition, she is a trained MS Nurse. She has over 14 years’ experience in Clinical Development, working for large Pharmaceutical Companies. She worked in CNS and Oncology therapeutic areas. She formerly worked as an Expert Clinical Manager at Novartis.
Senior Project Manager
Sandra is PhD in Molecular and Cellular Biology from the University of Strasbourg and has a Master’s degree in innovative project management from Strasbourg Management School. She formerly worked at Forenap Pharma as grant project manager and clinical project manager.
Gil has a Master’s degree in engineering from the École Nationale Supérieure d’Ingénieurs de Limoges, in electronics and telecommunications. He is in charge of software development.
Computer Science Engineer
Julien, with a Master’s degree in computer science from Polytech Paris-Sud, is in charge of databases and development of analysis processes.
Medical Innovative Solutions Program Leader
Antoine is PhD in Neuroscience and holds a Master’s degree of Pharmacology from the University of Strasbourg. He worked as a Senior Research Fellow at the Sleep Disorders Centre of the University of Strasbourg and at the Centre for Chronobiology of the University of Basel. He founded ChronoConseil, a sleep, circadian and light therapies consulting firm. He is author of more than 100 papers, book chapters or communications in conferences.
Senior Trade Advisor (external consultant)
Elsa leads the Life Sciences Department of Business France, New York. She specializes in accelerating the growth of disruptive technology in specific areas including mHealth devices, Medical Devices and Life Sciences.
She leads the innovation Program of the Galien Foundation to strengthen the collaboration between Healthtech/Biotech startups and Corporates. Previously, Elsa was with Siemens Healthcare as part of the strategy team. Elsa received a M.Sc. in Biomedical Engineering from Polytech.